Multifunctional ultrasmall nanoplatforms for vascular-targeted interstitial photodynamic therapy of brain tumors guided by real-time MRI.
Identifieur interne : 000245 ( Main/Exploration ); précédent : 000244; suivant : 000246Multifunctional ultrasmall nanoplatforms for vascular-targeted interstitial photodynamic therapy of brain tumors guided by real-time MRI.
Auteurs : Denise Bechet [France] ; Florent Auger [France] ; Pierre Couleaud [France] ; Eric Marty [France] ; Laura Ravasi [France] ; Nicolas Durieux [France] ; Corinne Bonnet ; François Plénat [France] ; Céline Frochot [France] ; Serge Mordon ; Olivier Tillement [France] ; Régis Vanderesse [France] ; François Lux [France] ; Pascal Perriat [France] ; François Guillemin [France] ; Muriel Barberi-Heyob [France]Source :
- Nanomedicine : nanotechnology, biology, and medicine [ 1549-9642 ] ; 2015.
Descripteurs français
- KwdFr :
- Angiographie par résonance magnétique, Animaux, Femelle, Gliome (), Gliome (traitement médicamenteux), Humains, Lignée cellulaire tumorale, Nanoparticules (), Nanoparticules (usage thérapeutique), Neuropiline 1 (), Neuropiline 1 (usage thérapeutique), Photosensibilisants (), Photosensibilisants (pharmacologie), Photothérapie dynamique (), Rat nude, Rats, Tumeurs du cerveau (), Tumeurs du cerveau (traitement médicamenteux).
- MESH :
- pharmacologie : Photosensibilisants.
- traitement médicamenteux : Gliome, Tumeurs du cerveau.
- usage thérapeutique : Nanoparticules, Neuropiline 1.
- Angiographie par résonance magnétique, Animaux, Femelle, Gliome, Humains, Lignée cellulaire tumorale, Nanoparticules, Neuropiline 1, Photosensibilisants, Photothérapie dynamique, Rat nude, Rats, Tumeurs du cerveau.
English descriptors
- KwdEn :
- Animals, Brain Neoplasms (drug therapy), Brain Neoplasms (radiography), Cell Line, Tumor, Female, Glioma (drug therapy), Glioma (radiography), Humans, Magnetic Resonance Angiography, Nanoparticles (chemistry), Nanoparticles (therapeutic use), Neuropilin-1 (chemistry), Neuropilin-1 (therapeutic use), Photochemotherapy (methods), Photosensitizing Agents (chemistry), Photosensitizing Agents (pharmacology), Rats, Rats, Nude.
- MESH :
- chemical , chemistry : Neuropilin-1, Photosensitizing Agents.
- chemistry : Nanoparticles.
- drug therapy : Brain Neoplasms, Glioma.
- methods : Photochemotherapy.
- chemical , pharmacology : Photosensitizing Agents.
- radiography : Brain Neoplasms, Glioma.
- therapeutic use : Nanoparticles, Neuropilin-1.
- Animals, Cell Line, Tumor, Female, Humans, Magnetic Resonance Angiography, Rats, Rats, Nude.
- mix :
Abstract
Photodynamic therapy (PDT) for brain tumors appears to be complementary to conventional treatments. A number of studies show the major role of the vascular effect in the tumor eradication by PDT. For interstitial PDT (iPDT) of brain tumors guided by real-time imaging, multifunctional nanoparticles consisting of a surface-localized tumor vasculature targeting neuropilin-1 (NRP-1) peptide and encapsulated photosensitizer and magnetic resonance imaging (MRI) contrast agents, have been designed. Nanoplatforms confer photosensitivity to cells and demonstrate a molecular affinity to NRP-1. Intravenous injection into rats bearing intracranial glioma exhibited a dynamic contrast-enhanced MRI for angiogenic endothelial cells lining the neovessels mainly located in the peripheral tumor. By using MRI completed by NRP-1 protein expression of the tumor and brain adjacent to tumor tissues, we checked the selectivity of the nanoparticles. This study represents the first in vivo proof of concept of closed-head iPDT guided by real-time MRI using targeted ultrasmall nanoplatforms. From the clinical editor: The authors constructed tumor vascular peptide targeting multifunctional silica-based nanoparticles, with encapsulated gadolinium oxide as MRI contrast agent and chlorin as a photosensitizer, as a proof of concept novel treatment for glioblastoma in an animal model.
Url:
DOI: 10.1016/j.nano.2014.12.007
PubMed: 25645959
Affiliations:
- France
- Auvergne-Rhône-Alpes, Grand Est, Hauts-de-France, Lorraine (région), Nord-Pas-de-Calais, Rhône-Alpes
- Lille, Lyon, Metz, Nancy, Vandœuvre-lès-Nancy
- Université de Lorraine
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Le document en format XML
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CRAN UMR 7039, Université de Lorraine, Vandœuvre-lès-Nancy, France; Laboratoire d'Anatomopathologie, CHU, Vandœuvre-lès-Nancy.</nlm:affiliation><orgName type="university">Université de Lorraine</orgName><country>France</country><placeName><settlement type="city">Nancy</settlement><settlement type="city">Metz</settlement><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region></placeName></affiliation></author><author><name sortKey="Frochot, Celine" sort="Frochot, Celine" uniqKey="Frochot C" first="Céline" last="Frochot">Céline Frochot</name><affiliation wicri:level="4"><nlm:affiliation>LRGP UMR 7274, CNRS, Nancy, France; LRGP UMR 7274, Université de Lorraine, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>LRGP UMR 7274, CNRS, Nancy, France; LRGP UMR 7274, Université de Lorraine, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Mordon, Serge" sort="Mordon, Serge" uniqKey="Mordon S" first="Serge" last="Mordon">Serge Mordon</name><affiliation><nlm:affiliation>INSERM U1189, Lille University Hospital, Lille.</nlm:affiliation><wicri:noCountry code="subField">Lille</wicri:noCountry></affiliation></author><author><name sortKey="Tillement, Olivier" sort="Tillement, Olivier" uniqKey="Tillement O" first="Olivier" last="Tillement">Olivier Tillement</name><affiliation wicri:level="3"><nlm:affiliation>ILM UMR 5306 CNRS, Claude Bernard-University, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>ILM UMR 5306 CNRS, Claude Bernard-University, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Vanderesse, Regis" sort="Vanderesse, Regis" uniqKey="Vanderesse R" first="Régis" last="Vanderesse">Régis Vanderesse</name><affiliation wicri:level="4"><nlm:affiliation>LCPM FRE 3564, CNRS, Nancy, France; LCPM FRE 3564, Université de Lorraine, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>LCPM FRE 3564, CNRS, Nancy, France; LCPM FRE 3564, Université de Lorraine, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Lux, Francois" sort="Lux, Francois" uniqKey="Lux F" first="François" last="Lux">François Lux</name><affiliation wicri:level="3"><nlm:affiliation>ILM UMR 5306 CNRS, Claude Bernard-University, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>ILM UMR 5306 CNRS, Claude Bernard-University, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Perriat, Pascal" sort="Perriat, Pascal" uniqKey="Perriat P" first="Pascal" last="Perriat">Pascal Perriat</name><affiliation wicri:level="3"><nlm:affiliation>ILM UMR 5306 CNRS, Claude Bernard-University, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>ILM UMR 5306 CNRS, Claude Bernard-University, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Guillemin, Francois" sort="Guillemin, Francois" uniqKey="Guillemin F" first="François" last="Guillemin">François Guillemin</name><affiliation wicri:level="4"><nlm:affiliation>CRAN UMR 7039, CNRS, Vandœuvre-lès-Nancy, France; 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CRAN UMR 7039, Université de Lorraine, Vandœuvre-lès-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CRAN UMR 7039, CNRS, Vandœuvre-lès-Nancy, France; CRAN UMR 7039, Université de Lorraine, Vandœuvre-lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Auger, Florent" sort="Auger, Florent" uniqKey="Auger F" first="Florent" last="Auger">Florent Auger</name><affiliation wicri:level="3"><nlm:affiliation>IMPRT (Institut de Médecine Prédictive et de Recherche Thérapeutique) IFR 114, U 837 INSERM, CHRU de Lille, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IMPRT (Institut de Médecine Prédictive et de Recherche Thérapeutique) IFR 114, U 837 INSERM, CHRU de Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Couleaud, Pierre" sort="Couleaud, Pierre" uniqKey="Couleaud P" first="Pierre" last="Couleaud">Pierre Couleaud</name><affiliation wicri:level="4"><nlm:affiliation>LRGP UMR 7274, CNRS, Nancy, France; LRGP UMR 7274, Université de Lorraine, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>LRGP UMR 7274, CNRS, Nancy, France; LRGP UMR 7274, Université de Lorraine, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Marty, Eric" sort="Marty, Eric" uniqKey="Marty E" first="Eric" last="Marty">Eric Marty</name><affiliation wicri:level="1"><nlm:affiliation>Private executive, Marcilly-sur-Eure, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Private executive, Marcilly-sur-Eure</wicri:regionArea><wicri:noRegion>Marcilly-sur-Eure</wicri:noRegion><wicri:noRegion>Marcilly-sur-Eure</wicri:noRegion></affiliation></author><author><name sortKey="Ravasi, Laura" sort="Ravasi, Laura" uniqKey="Ravasi L" first="Laura" last="Ravasi">Laura Ravasi</name><affiliation wicri:level="3"><nlm:affiliation>IMPRT (Institut de Médecine Prédictive et de Recherche Thérapeutique) IFR 114, U 837 INSERM, CHRU de Lille, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IMPRT (Institut de Médecine Prédictive et de Recherche Thérapeutique) IFR 114, U 837 INSERM, CHRU de Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Durieux, Nicolas" sort="Durieux, Nicolas" uniqKey="Durieux N" first="Nicolas" last="Durieux">Nicolas Durieux</name><affiliation wicri:level="3"><nlm:affiliation>IMPRT (Institut de Médecine Prédictive et de Recherche Thérapeutique) IFR 114, U 837 INSERM, CHRU de Lille, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>IMPRT (Institut de Médecine Prédictive et de Recherche Thérapeutique) IFR 114, U 837 INSERM, CHRU de Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Bonnet, Corinne" sort="Bonnet, Corinne" uniqKey="Bonnet C" first="Corinne" last="Bonnet">Corinne Bonnet</name><affiliation><nlm:affiliation>Laboratoire d'Anatomopathologie, CHU, Vandœuvre-lès-Nancy.</nlm:affiliation><wicri:noCountry code="subField">Vandœuvre-lès-Nancy</wicri:noCountry></affiliation></author><author><name sortKey="Plenat, Francois" sort="Plenat, Francois" uniqKey="Plenat F" first="François" last="Plénat">François Plénat</name><affiliation wicri:level="4"><nlm:affiliation>CRAN UMR 7039, CNRS, Vandœuvre-lès-Nancy, France; CRAN UMR 7039, Université de Lorraine, Vandœuvre-lès-Nancy, France; Laboratoire d'Anatomopathologie, CHU, Vandœuvre-lès-Nancy.</nlm:affiliation><orgName type="university">Université de Lorraine</orgName><country>France</country><placeName><settlement type="city">Nancy</settlement><settlement type="city">Metz</settlement><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region></placeName></affiliation></author><author><name sortKey="Frochot, Celine" sort="Frochot, Celine" uniqKey="Frochot C" first="Céline" last="Frochot">Céline Frochot</name><affiliation wicri:level="4"><nlm:affiliation>LRGP UMR 7274, CNRS, Nancy, France; LRGP UMR 7274, Université de Lorraine, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>LRGP UMR 7274, CNRS, Nancy, France; LRGP UMR 7274, Université de Lorraine, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Mordon, Serge" sort="Mordon, Serge" uniqKey="Mordon S" first="Serge" last="Mordon">Serge Mordon</name><affiliation><nlm:affiliation>INSERM U1189, Lille University Hospital, Lille.</nlm:affiliation><wicri:noCountry code="subField">Lille</wicri:noCountry></affiliation></author><author><name sortKey="Tillement, Olivier" sort="Tillement, Olivier" uniqKey="Tillement O" first="Olivier" last="Tillement">Olivier Tillement</name><affiliation wicri:level="3"><nlm:affiliation>ILM UMR 5306 CNRS, Claude Bernard-University, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>ILM UMR 5306 CNRS, Claude Bernard-University, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Vanderesse, Regis" sort="Vanderesse, Regis" uniqKey="Vanderesse R" first="Régis" last="Vanderesse">Régis Vanderesse</name><affiliation wicri:level="4"><nlm:affiliation>LCPM FRE 3564, CNRS, Nancy, France; LCPM FRE 3564, Université de Lorraine, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>LCPM FRE 3564, CNRS, Nancy, France; LCPM FRE 3564, Université de Lorraine, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Lux, Francois" sort="Lux, Francois" uniqKey="Lux F" first="François" last="Lux">François Lux</name><affiliation wicri:level="3"><nlm:affiliation>ILM UMR 5306 CNRS, Claude Bernard-University, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>ILM UMR 5306 CNRS, Claude Bernard-University, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Perriat, Pascal" sort="Perriat, Pascal" uniqKey="Perriat P" first="Pascal" last="Perriat">Pascal Perriat</name><affiliation wicri:level="3"><nlm:affiliation>ILM UMR 5306 CNRS, Claude Bernard-University, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>ILM UMR 5306 CNRS, Claude Bernard-University, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Guillemin, Francois" sort="Guillemin, Francois" uniqKey="Guillemin F" first="François" last="Guillemin">François Guillemin</name><affiliation wicri:level="4"><nlm:affiliation>CRAN UMR 7039, CNRS, Vandœuvre-lès-Nancy, France; CRAN UMR 7039, Université de Lorraine, Vandœuvre-lès-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CRAN UMR 7039, CNRS, Vandœuvre-lès-Nancy, France; CRAN UMR 7039, Université de Lorraine, Vandœuvre-lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Barberi Heyob, Muriel" sort="Barberi Heyob, Muriel" uniqKey="Barberi Heyob M" first="Muriel" last="Barberi-Heyob">Muriel Barberi-Heyob</name><affiliation wicri:level="4"><nlm:affiliation>CRAN UMR 7039, CNRS, Vandœuvre-lès-Nancy, France; CRAN UMR 7039, Université de Lorraine, Vandœuvre-lès-Nancy, France. Electronic address: muriel.barberi@univ-lorraine.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CRAN UMR 7039, CNRS, Vandœuvre-lès-Nancy, France; CRAN UMR 7039, Université de Lorraine, Vandœuvre-lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author></analytic><series><title level="j">Nanomedicine : nanotechnology, biology, and medicine</title><idno type="eISSN">1549-9642</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Brain Neoplasms (drug therapy)</term><term>Brain Neoplasms (radiography)</term><term>Cell Line, Tumor</term><term>Female</term><term>Glioma (drug therapy)</term><term>Glioma (radiography)</term><term>Humans</term><term>Magnetic Resonance Angiography</term><term>Nanoparticles (chemistry)</term><term>Nanoparticles (therapeutic use)</term><term>Neuropilin-1 (chemistry)</term><term>Neuropilin-1 (therapeutic use)</term><term>Photochemotherapy (methods)</term><term>Photosensitizing Agents (chemistry)</term><term>Photosensitizing Agents (pharmacology)</term><term>Rats</term><term>Rats, Nude</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Angiographie par résonance magnétique</term><term>Animaux</term><term>Femelle</term><term>Gliome ()</term><term>Gliome (traitement médicamenteux)</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Nanoparticules ()</term><term>Nanoparticules (usage thérapeutique)</term><term>Neuropiline 1 ()</term><term>Neuropiline 1 (usage thérapeutique)</term><term>Photosensibilisants ()</term><term>Photosensibilisants (pharmacologie)</term><term>Photothérapie dynamique ()</term><term>Rat nude</term><term>Rats</term><term>Tumeurs du cerveau ()</term><term>Tumeurs du cerveau (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Neuropilin-1</term><term>Photosensitizing Agents</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Nanoparticles</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Brain Neoplasms</term><term>Glioma</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Photochemotherapy</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Photosensibilisants</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Photosensitizing Agents</term></keywords><keywords scheme="MESH" qualifier="radiography" xml:lang="en"><term>Brain Neoplasms</term><term>Glioma</term></keywords><keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Nanoparticles</term><term>Neuropilin-1</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Gliome</term><term>Tumeurs du cerveau</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Nanoparticules</term><term>Neuropiline 1</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line, Tumor</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Angiography</term><term>Rats</term><term>Rats, Nude</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Angiographie par résonance magnétique</term><term>Animaux</term><term>Femelle</term><term>Gliome</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Nanoparticules</term><term>Neuropiline 1</term><term>Photosensibilisants</term><term>Photothérapie dynamique</term><term>Rat nude</term><term>Rats</term><term>Tumeurs du cerveau</term></keywords><keywords scheme="mix" xml:lang="en"><term>brain tumor</term><term>iPDT</term><term>multifunctional nanoplateforms</term><term>real-time MRI</term><term>targeting</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Photodynamic therapy (PDT) for brain tumors appears to be complementary to conventional treatments. A number of studies show the major role of the vascular effect in the tumor eradication by PDT. For interstitial PDT (iPDT) of brain tumors guided by real-time imaging, multifunctional nanoparticles consisting of a surface-localized tumor vasculature targeting neuropilin-1 (NRP-1) peptide and encapsulated photosensitizer and magnetic resonance imaging (MRI) contrast agents, have been designed. Nanoplatforms confer photosensitivity to cells and demonstrate a molecular affinity to NRP-1. Intravenous injection into rats bearing intracranial glioma exhibited a dynamic contrast-enhanced MRI for angiogenic endothelial cells lining the neovessels mainly located in the peripheral tumor. By using MRI completed by NRP-1 protein expression of the tumor and brain adjacent to tumor tissues, we checked the selectivity of the nanoparticles. This study represents the first in vivo proof of concept of closed-head iPDT guided by real-time MRI using targeted ultrasmall nanoplatforms. From the clinical editor: The authors constructed tumor vascular peptide targeting multifunctional silica-based nanoparticles, with encapsulated gadolinium oxide as MRI contrast agent and chlorin as a photosensitizer, as a proof of concept novel treatment for glioblastoma in an animal model.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Grand Est</li><li>Hauts-de-France</li><li>Lorraine (région)</li><li>Nord-Pas-de-Calais</li><li>Rhône-Alpes</li></region><settlement><li>Lille</li><li>Lyon</li><li>Metz</li><li>Nancy</li><li>Vandœuvre-lès-Nancy</li></settlement><orgName><li>Université de Lorraine</li></orgName></list><tree><noCountry><name sortKey="Bonnet, Corinne" sort="Bonnet, Corinne" uniqKey="Bonnet C" first="Corinne" last="Bonnet">Corinne Bonnet</name><name sortKey="Mordon, Serge" sort="Mordon, Serge" uniqKey="Mordon S" first="Serge" last="Mordon">Serge Mordon</name></noCountry><country name="France"><region name="Grand Est"><name sortKey="Bechet, Denise" sort="Bechet, Denise" uniqKey="Bechet D" first="Denise" last="Bechet">Denise Bechet</name></region><name sortKey="Auger, Florent" sort="Auger, Florent" uniqKey="Auger F" first="Florent" last="Auger">Florent Auger</name><name sortKey="Barberi Heyob, Muriel" sort="Barberi Heyob, Muriel" uniqKey="Barberi Heyob M" first="Muriel" last="Barberi-Heyob">Muriel Barberi-Heyob</name><name sortKey="Couleaud, Pierre" sort="Couleaud, Pierre" uniqKey="Couleaud P" first="Pierre" last="Couleaud">Pierre Couleaud</name><name sortKey="Durieux, Nicolas" sort="Durieux, Nicolas" uniqKey="Durieux N" first="Nicolas" last="Durieux">Nicolas Durieux</name><name sortKey="Frochot, Celine" sort="Frochot, Celine" uniqKey="Frochot C" first="Céline" last="Frochot">Céline Frochot</name><name sortKey="Guillemin, Francois" sort="Guillemin, Francois" uniqKey="Guillemin F" first="François" last="Guillemin">François Guillemin</name><name sortKey="Lux, Francois" sort="Lux, Francois" uniqKey="Lux F" first="François" last="Lux">François Lux</name><name sortKey="Marty, Eric" sort="Marty, Eric" uniqKey="Marty E" first="Eric" last="Marty">Eric Marty</name><name sortKey="Perriat, Pascal" sort="Perriat, Pascal" uniqKey="Perriat P" first="Pascal" last="Perriat">Pascal Perriat</name><name sortKey="Plenat, Francois" sort="Plenat, Francois" uniqKey="Plenat F" first="François" last="Plénat">François Plénat</name><name sortKey="Ravasi, Laura" sort="Ravasi, Laura" uniqKey="Ravasi L" first="Laura" last="Ravasi">Laura Ravasi</name><name sortKey="Tillement, Olivier" sort="Tillement, Olivier" uniqKey="Tillement O" first="Olivier" last="Tillement">Olivier Tillement</name><name sortKey="Vanderesse, Regis" sort="Vanderesse, Regis" uniqKey="Vanderesse R" first="Régis" last="Vanderesse">Régis Vanderesse</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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